Cells naturally control gene expression using a variety of RNA, protein, and DNA modifying regulators. It has long been recognized that interactions between these regulators could lead to computational operations similar to electronic circuits. The design and construction of synthetic circuits, a synthetic biology variant of metabolic engineering, has been applied to a wide range of cellular regulatory processes. Many research groups have worked to modify existing biosynthetic pathways, while others have attempted to introduce biological pathways into model microorganisms. In most cases, metabolic pathways are designed or redesigned to optimize the productivity of microorganisms. Building synthetic circuits remains one of the biggest challenges in the field, and even simple circuits require a lot of labor to build and lack their natural counterparts in performance. Our designers incorporated phage λ into the design of synthetic circuits. This phage grows lytically, forming stable lysogens, and can transition from this regulated state to lytic growth. Genetic selection can be used for every behavior.
Our advanced circuit design concepts pave the way for more complex synthetic cellular regulation. Creative Biolabs' complete DNA synthesis platform provides a one-stop shop for all synthetic circuit design solutions.
Creative Biolabs' complete DNA synthesis platform is a one-stop shop for all synthetic biology solutions.
Creative Biolabs has a complete library of functional components and we use bacteriophage lambda to construct vectors. The phage lambda gene regulatory circuit is bistable. Bistable gene regulatory circuits can adopt two alternative stable states. In phage λ, these states are the lytic and lysogenic states. Furthermore, phage λ can switch from a lysogenic state to a lytic state.
Creative Biolabs' synthetic assembly technology provides custom and cost-effective gene synthesis services capable of constructing sequences up to 150 kbp.
Our standard analysis usually includes mass spectrometry and purity determination (through HPLC). Every design and development will meet the regulations and save customers’ time and cost.
Creative Biolabs can meet the needs of customers by providing design and synthesis solutions of gene circuits using phage on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
