Phages are the most abundant biological entities in the environment, are relatively easy to isolate and reproduce, and are highly evolved to kill specific bacterial strains, species, and sometimes even genera. Phages are highly evolved nanomachines that recognize bacterial cell walls, transmit genetic information, and kill or transform their targets with unparalleled specificity. For a long time, the use of transgenic phages was limited to phage display methods and basic research. This is mainly because phage engineering is a complex and time-consuming task that is only available for a few well-characterized model phages. Recent advances in sequencing technologies and molecular biology have yielded rapid and precise tools capable of modifying less-characterized phages. These approaches will pave the way for the development of modularly designed bacteriophages as multifunctional biologics to effectively control multidrug-resistant bacteria and provide new tools for pathogen detection, drug development, and more.
Powered by science, our team of experts brings expertise and a proven track record of scaling up biologics to help ensure cost and time savings at every stage of your phage multifunctional biologics development process.
We developed the potential of novel phage engineering methods to improve, customize, and market phage-based antimicrobials.
Phages engineered to carry reporter genes are expressed during infection of the target bacteria and subsequently detected. These reporter phages combine highly specific phage-host interactions with the sensitivity of the reporter system used, ultimately enabling rapid detection of very few bacterial cells.
We understand the challenges of phage multifunctional biologics and the need for flexibility and speed, and can provide you with strategic guidance and flexible solutions tailored based on combined capabilities and experience.
The substrate for every phage engineering is a nucleotide sequence, and next-generation sequencing technology enables rapid and reliable sequencing of novel isolates. Creative Biolabs provides isolation of modified phages.
Our analytical capabilities include rapid identification and characterization of your recombinant protein or formulation, development, and data generation for regulatory submissions. Both development and manufacturing analytical methods are created by the same team to avoid delays and errors due to handovers. Our extensive analytical services and capabilities include: glycan analysis, ELISA assays for product and impurity assessment, gel- and capillary-based electrophoresis, gel- and capillary-based isoelectric focusing, residual DNA detection, cell-based bioassays, immunological and colorimetric assays, chromatography and mass spectrometry.
Creative Biolabs can meet the needs of customers by providing phages as functional biologics development solutions on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
