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GMP and Non-GMP Phage Production

GMP and non-GMP Phages Production

In recent years, the successful application of bacteriophages in food safety, agriculture, aquaculture, and even human health has attracted much attention. Many companies are commercializing phage or phage-based products for therapeutic purposes. However, this technology is still in the development stage, and some challenges need to be overcome before phages can be widely used to control pathogens. The development of effective phage production methods is one of the main obstacles. Creative Biolabs can develop complete production processes for lysis and filamentous bacteriophages or optimize existing production processes. Our experience with different bacteriophages allows us to develop and optimize processes from Petri dishes to bioreactors and from laboratory-scale purification to pilot-scale production. The optimized manufacturing process uses the most advanced technology and optimized upstream and downstream processes to provide high phage titer, high yield, and high purity in a cost-effective manner.

Our Services

As a leading expert in the development of bacteriophages for treatment, Creative Biolabs specializes in the production of various bacteriophages. Our custom manufacturing plan includes laboratory synthesis and rapid scale-up. We provide customized production services in a timely manner based on customer needs. Our services are listed as follows, but are not limited to:

  • Production of GMP and non-GMP phages
  • Laboratory synthesis and rapid scale-up
  • Production of phage-resistant strains

Types of Phages Produced

  • Diagnostics
    • Listeria phages
  • Food/Agriculture applications
    • Listeria phages
    • Salmonella phages
    • Campylobacter phages
  • Cosmetics
    • Propionibacterium phages
  • Probiotics
    • Escherichia phages
  • Veterinary
    • Listeria phages
    • Salmonella phages
    • Pseudomonas phages
  • Human therapeutics
    • Escherichia phages
    • Acinetobacter phages
    • Pseudomonas phages
    • Staphylococcus phages
    • Clostridium phages

Process Activities

  • Possible deliverables: crude phage lysate, concentrated crude phage lysate, purified concentrated phage material, various intermediates
  • Upstream scale: Erlenmeyer flask, 1L, 15L, 50L, continuous
  • Downstream scale: The downstream capacity matches the fermentation scale. This means that one fermentation batch can be purified in a single run, without the need for batches
  • Downstream options: IEX (Q, S), gel filtration, diafiltration, affinity, etc.

Our Advantages

  • Dedication to quality
  • Extensive experience
  • Open communication
  • Cutting edge science
  • Global delivery
  • Strict quality control
Our advantages of GMP and non-GMP phages production services

Creative Biolabs can meet the needs of customers by providing GMP and non-GMP phages production services on time and on budget. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for each professional for your project. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).

Biophage Technology

Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.

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