Microbicide materials are produced in a variety of forms, including gels, creams, suppositories, films, or sponges or rings that release the active ingredient over time. A number of materials have been tried or shown promise as microbicides formulations. Temperate phages are not suitable for natural phage therapy because they do not lyse all host cells and have been investigated as materials to display active ingredients for targeted therapeutic delivery. Recently, phage engineering has been greatly expanded in biomedical applications, including tissue engineering and drug delivery. Through genetic engineering, the coating covering the surface of the M13 phage is capable of delivering a variety of therapeutic peptides and proteins. The resulting phages can self-assemble nanofibrous network structures that closely resemble the cellular microenvironment. These structures can influence cell fate through biochemical and physical cues that control the matrix. These phages and their matrices may aid in the development of topical therapeutic materials, as phages can deliver a large number of therapeutic molecules without compromising phage integrity.
Fig 1. Schematic of the M13 phage peptide library and gene construction. (Bhattarai S R, et al., 2012) At Creative Biolabs, we are committed to developing and delivering innovative antimicrobial materials that will have a meaningful impact on bacterial therapy. For us, this means focusing on the latest scientific advances, other researchers, and advocates to ensure that our novel materials bring value to the treatment of drug-resistant bacteria.
We genetically engineered M13 phage to display the desired fusion protein or peptide on its coat surface protein and developed microbicidal materials.
Creative Biolabs can meet the needs of customers by providing phage-based microbicide materials development solutions on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
