In addition to specific antibiotic resistance, bacterial biofilm formation can lead to another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficulty in penetration of drugs into bacterial cells through biofilm structures, compromised host immune responses, and Accumulation of various biologically active substances. Depolymerases are phage-derived enzymes that facilitate the early stages of phage infection by degrading extracellular material that encapsulates bacteria and may also help reach phage receptors. Depolymerase activity is particularly interesting in removing biofilms as it alters the EPS matrix and reduces bacterial virulence. They are able to degrade capsular polysaccharides, exopolysaccharides and O-polysaccharide chains from lipopolysaccharides and peptidoglycans. All of these substances may constitute the envelope of some free-living bacteria, but they are mostly important components of the biofilm matrix. Depolymerases can bind to virions, form part of the phage particle, or be in a soluble form. Since phage-encoded depolymerases are capable of degrading polysaccharides in bacterial capsules and biofilm matrices, phages encoding these enzymes may be more readily accessible to bacterial hosts, leading to infection.
We offer a full suite of Phage-Derived Depolymerases services, including bioprocessing, formulation screening and analytical development for a variety of products. The group provides solutions for the development and biomanufacturing of different types of bacteriophages and bacteriophage derivatives. Our services are listed as follows, but are not limited to:
Fig 1. Alternative strategies in the fight against mature biofilm or its formation. (Topka-Bielecka G, et al. 2021)
Creative Biolabs can meet the needs of customers by providing phage-derived depolymerases production services on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
