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Phage Display Immune Library Construction

The immune library is generated from an antibody library derived from immune or immune donor B cells, which makes it easy to use a limited set of antigens. Due to this trend, their size is usually relatively small. However, compared with the original library, the immune library is not suitable for recognizing antibody fragments against a large number of antigens (especially self-antigens). Constructing an immune library can increase the affinity of the final antibody to the target protein. Creative Biolabs can generate a highly diverse antibody library for phage display, providing the most complex binding agent for your project. Our phage display vector and display system are unique and have many advantages. We have also made custom scFv libraries from mice and humans, and can make various other sources (rabbit, sheep, cow), as long as antibody sequence information is available.

Our Services

Immune phage display library constructed from camel, alpaca, llama, or shark can generate VHH or VNAR with high affinity and specificity. At Creative Biolabs, we have successfully produced monoclonal antibodies from alpacas, camels, sharks, rabbit, sheep, cow, and mice. Our services are listed as follows, but are not limited to:

  • Construction and screening of an immune library
  • Library capacity detection
  • QC of Immune phage display library

Advantages of the Immune Libraries

  • Higher chance of obtaining the required VHH or VNAR single domain antibody
  • Better affinity and specificity
  • Easier to obtain antibodies that recognize different epitopes

The Most Commonly Used Phages

Lysogenic single-stranded filamentous bacteriophages, such as M13, f1, and fd.

Our Capabilities

  • The library capacity is measured under 109 to 1016 different binders.
  • We can provide you with many types of libraries: scFv, Fab, and VHH formats.
  • Perform library screening to identify binders with the best affinity.
  • The construction and screening of the immune library can be tailored according to your research for obtaining high specificity and stability

Our Advantages

Advantages of Our Immune Library for Your Project

At Creative Biolabs, the choice of constructing and screening immune libraries through phage display will enable you to produce monoclonal antibodies with the highest affinity for any species. For more information or to obtain a quotation for immune library construction services with phage display, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).

Biophage Technology

Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.

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