Proteolytic enzymes have regulatory roles in cellular processes, including hormone release, coagulation, and complement. Such enzymes also function as pathogenic factors in various diseases including inflammatory diseases, malignant tumors, and cancers. Since modification of natural protease inhibitors seems laborious, and synthetic protease inhibitors are accompanied by deleterious or even dangerous effects due to their complex metabolism, phage display technology has been proposed as a method for combining combinatorial chemical and biological synthesis capabilities. Practical methods to find suitable inhibitors. The role of phage display is primarily focused on the isolation of ligands (< 100 amino acids), which contain special inhibitory scaffolds and provide information on the functional groups required for efficient binding and their relative positions. The identified candidates are then further modified to develop protease inhibitors in the form of peptidomimetics. Creative Biolabs can help you achieve greater success by providing phage display-derived protein drug development solutions. Our analytical and custom test development experts can provide you with comprehensive support before, during, and after your experiments.
Fig 1. Phage-based target discovery (Wan X, et al., 2021) We have the experience and capabilities to design, develop, optimize and address all stages of protein drug process development using a variety of approaches. Our experts will provide and help design the optimal solution based on phage technology for your protein drug project and help you troubleshoot throughout the process. Our services are listed below, but are not limited to:
Phage display technology has been proposed as a practical approach to combining the synthetic capabilities of combinatorial chemistry and biology to discover suitable inhibitors.
Phage display technology has been proposed as a practical approach to combining the synthetic capabilities of combinatorial chemistry and biology to discover suitable inhibitors. Phage display methods can be used to select mutants with retained functions.
These protein scaffolds with appropriate properties have undeniable advantages in drug targeting. Phage display has facilitated the development of antibodies molecules, which are designed based on the Z domain of protein A and are considered a viable and sometimes superior alternative to antibodies.
Creative Biolabs can meet the needs of customers by providing protein drugs development solutions on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
