The entire phage particle has many inherent characteristics, making it an ideal vaccine delivery vehicle for phage display and DNA vaccines. Phage vaccines are cheap and easy to produce on a large scale. Bacteriophages are highly stable. Dilution of lambda phage in water will only cause a slight drop in titer within 2 weeks. The phage can be stable even within 24 hours in the pH range of 3-11, so it is possible to successfully oral phage vaccine. Since the displayed protein is fused with coat protein, it is not susceptible to nuclease degradation under the protective protein matrix. Unlike other viral vectors, bacteriophages cannot replicate in eukaryotic hosts. Phage particles have a natural immune-stimulating effect. They carry enough CD4+ T cell epitopes to trigger an immune response. Vaccination with phage particles also induces a highly immunogenic signal against the phage coat protein, which provides an easily detectable marker to confirm the effectiveness of the animal's vaccination. In addition, high phage antibody titers will not interfere with the immune response against the expressed DNA vaccine antigen, and, if any, are more likely to target the phage effectively to APC.
Our researchers can help you achieve greater success with phage-based vaccine development solutions. We have professionals who listen to your needs carefully, and they can provide you with comprehensive support before, during and after your experiment. We can provide these solutions listed as follows:
There is a lack of optimization at all stages of manufacturing. We provide optimization and quality inspections that help to rapidly expand the scale of vaccine production
Environmental conditions, such as heat, light, and radiation, can affect the quality and purity of vaccines. Different techniques are being used to assess vaccine quality.
When designing any type of vaccine, an equally important factor is the route of administration. We provide a model of the route of administration for vaccine development
We have established a phage-based vaccine campaign platform and have a technical team of multi-disciplinary scientific researchers to ensure that we can provide services to customers efficiently, accurately and in a timely manner. The families of phages used as vaccine platforms are listed as follows:
Table 1. Structure and application of families of phages used as vaccine platforms
| Phage | Structure | Major Dimensions | Vaccine applications | Figure |
|---|---|---|---|---|
| Filamentous | Filamentous | 900 nm × 7 nm | Parasites Fungi Influenza Melanoma Breast cancer |  |
| T4 | Icosahedron + tail | 120 nm × 86 nm | Anthrax Plague Lung cancer |  |
| T7 | Icosahedron + | 56 nm × 29 nm | Influenza Foot and mouth disease Epstein–Barr Melanoma Breast cancer |  |
| λ | Icosahedron + | 60 nm × 150 nm | Hepatitis B Breast cancer Liver cancer |  |
| MS2 | Icosahedron | 26 nm | Foot and mouth disease HPV Zika |  |
| Qβ | Icosahedron | 28 nm | Breast cancer Melanoma |  |
Creative Biolabs can meet the needs of customers by providing vaccines development solutions on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
