The ability of engineered phages to deliver drugs directly to specific cancer cells has the potential to minimize the side effects and off-target toxicity of more traditional cancer therapies. Phages can be associated with drugs that has low water solubility, allowing for enhanced delivery and lower doses administered. The endocytosis of the phage particles then delivers the gene or drug cargo specifically into the target eukaryotic cells. Phage capsids can be used to transport drugs to specific tissues and prevent drug degradation. The single-stranded RNA bacteriophage MS2 is commonly used in drug delivery because its coat protein spontaneously assembles into virus-like particles (VLPs) that do not contain genetic material when expressed in E. coli. At the same time, the MS2 coat protein can tolerate the insertion of tags at multiple positions, so that the active ingredients that can be carried include drugs, enzymes, nucleic acids, homing peptides, etc. , so that they can target specific animal tissue parts and improve their resistance.
Fig 1. General concept of using phage for drug and gene delivery. (Ju Z, et al. 2017)Phage peptides/proteins can be directly self-assembled into phage-mimicking nanoparticles, which can be used for self-navigating drug delivery nanocarriers. We provide filamentous phage-mediated delivery construction services. They are listed as follows, but are not limited to:
Eukaryotic viruses can provide excellent gene delivery and transduction despite their natural tropism for mammalian cells. If the excellent performance can be combined with phage particles, the gene transfer efficiency of target phage will definitely be improved.
Phages have the ability to load antibodies and retain their biological activity. Animal studies show that phages can carry drugs to their side walls, penetrate the blood barrier, and then deliver the drug to the brain
Liposomes, which are artificial phospholipid vesicles, have been developed as drug carriers with biomedical properties. The combination of phage particles and liposomes to form new phage-liposome complexes not only stabilizes the liposomes, but also helps the liposomes reach specific cells. This provides a new way to deliver liposomes to desired targets.
Phage vectors consist of a substantially complete phage genome, usually the M13 phage, into which DNA encoding a protein or peptide of interest is inserted.
Creative Biolabs can meet the needs of customers by providing phagemid vectors development for drug delivery services on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
