Phages, viruses that infect bacteria, are an underutilized biological resource with enormous potential for pathogen control and microbiome editing. Phages are biological entities that can control host populations. The ecological relevance of bacteriophages to microbial systems has been extensively explored in the aquatic environment, and microbial communities spread across our planet and play key roles in the biosphere, agriculture, biotechnology, and human health. And our tools for editing bacterial communities are very limited. Antibiotics are usually broad-spectrum and kill not only harmful bacteria but also probiotics. Phages have a highly specific host range and are therefore expected to precisely knock out strains in microbial communities or edit specific genes in microbial communities. The emergence of phage-based (chemical-free) precise biological control and microbiome editing to enhance, suppress or modulate microbial activity important for public health, food security, and more sustainable energy production and water reuse. The integration of synthetic biology facilitates the creation of new phage chassis and modular genetic components.
Fig 1. Development of phage-resistant bacterial strains and host-range mutant phages (h-mutant) in nature. (Jones J B, et al., 2007) Phages play a crucial role in determining the composition and activity of microbial communities. Our scientists provide solutions of microbial community control by the phage to solve phage-related problems when you are faced with your projects.
Phage-based disease control management is a dynamic process that requires continuous adjustment of phage production to effectively combat potential adaptive pathogens.
Our scientists target functions by using phages as vectors to deliver various regulatory interventions - such as specific genes that introduce new functions into the community (which are beneficial to the host).
The way of our scientists maintains high phage populations is to use them with bacteria that are able to persist in the plant environment and are susceptible to phages.
Our scientists address host resistance to phages by increasing their host range, gene editing, and other techniques.
Creative Biolabs can meet the needs of customers by providing solutions of microbial community control by phage on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
