Some phage-encoded enzymes may help treat bacterial infections and biofilms. These phage-derived enzymes or enzyme biogenesis can be used as an alternative to antibiotics to promote human and animal health. Their efficacy has been demonstrated in some preclinical studies, but these products are still in development. Under current safety standards and regulations, the application of bacteriophage products is easier than using the bacteriophages themselves. Two main types of phage-degrading enzymes can be used to remove biofilms: lysins and depolymerases. Lysin has bactericidal effect on sensitive bacteria. They break peptidoglycan bonds and degrade bacterial cell walls and biofilm structures. Depolymerases can facilitate the early stages of phage infection by degrading extracellular material that encapsulates bacteria and may also help reach phage receptors. Depolymerase activity is particularly interesting in removing biofilms as it alters the EPS matrix and reduces bacterial virulence. Our team is currently developing phage-based therapeutics to combat bacterial infections, and provides customers with a full suite of phage-derived enzyme services, including bioprocessing, formulation screening, and assay development for a variety of products.
We use a unique manufacturing method that removes all forms of nucleic acid (linear, circular, single-stranded or double-stranded DNA/RNA) very efficiently, and facilitates purification by reducing viscosity. This also increases process efficiency and makes the final product fully compliant with regulatory and technical process requirements. Our services are listed as follows, but are not limited to:
In order to extract proliferating phages from host microorganisms during production, cell lysis must be performed, which results in the growth medium being saturated with nucleic acids (DNA and RNA) and intracellular components, making the solution viscous and very difficult to handle and purify. We use a unique phage production technology platform to solve the above problems. Our technology has the following characteristics:
Creative Biolabs can meet the needs of customers by providing phage-derived enzyme production services on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
