Membrane receptors are essential for the intercellular biochemical and electrical signal transduction of basic physiological functions. Therefore, the pharmaceutical industry tends to focus on the development of drugs that target membrane receptors. Phage display technology provides a rapid method by which proteins and peptides that specifically bind to predetermined molecular targets can be isolated from extremely complex combinatorial libraries. Phage display can advance receptor-based research in many important ways. In the phage display strategy, as many as 109 differently arranged peptides are expressed on the surface of the filamentous phage. Therefore, peptides that can bind to target molecules in vitro and even target tissues in vivo can be identified. In recent years, a series of libraries displaying degenerate peptides of different lengths have been constructed, and specific ligands for cell surface receptors, such as integrins, have been isolated. After biopanning in vivo and intravenous injection of phage libraries into mice, peptides targeting different organs or tumors have been rescued. In one application, isolated peptide ligands have been used to direct cytotoxic drugs to the tumor vasculature of mice.
Phage display technology provides a rapid method by which proteins and peptides that specifically bind to predetermined molecular targets can be isolated from extremely complex combinatorial libraries. At Creative Biolabs, our scientists can provide the listed solutions to deal with your receptor and ligand identification.
Phage display technology is an in vitro screening technology used to identify ligands for proteins and other macromolecules. The key to phage display technology is the ability to express peptide or protein sequences as fusions with phage coat proteins. The classification of phage display systems are
We have provided a large number of phage display library construction to meet your various needs. We believe that our phage display technology can help you gain new opportunities in immunotherapy, drug discovery, and functional genomics. Our phage display libraries are listed as follows, but are not limited to:
A method for rapid screening of the ability of cDNA products to bind to predetermined targets will certainly advance the field of functional genomics.
More and more receptor ligands have been studied using phage display.
Cloned phage antibodies are usually used as single-chain Fv fragments or Fab fragments for phage display.
Creative Biolabs can meet the needs of customers by providing solutions in receptor and ligand identification on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
