Synthetic biology involves the design of biological organisms through the use of modular and generalizable designs, with the ultimate goal of developing useful solutions to real-world problems. One such problem involves bacterial biofilms, which are critical in the pathogenesis of many clinically important infections and are difficult to eradicate because they exhibit resistance to antimicrobial therapy and removal by the host immune system. Biofilms are groups of bacteria associated with surfaces. Their main feature is the attachment of bacteria within biofilms to other bacterial cells and surfaces via an extracellular polymeric matrix. Biofilms are capable of adhering to various surfaces, both biotic and abiotic, including human tissue, medical devices, and other materials. On these surfaces, biofilms are a major threat to infectious disease and economic loss. To address this issue, our team co-designed and developed an engineered bacteriophage that expresses a biofilm-degrading enzyme to simultaneously attack bacterial cells in biofilms and the biofilm matrix composed of extracellular polymers.
Fig 1. Main phage-based treatments for biofilm removal. (Ferriol-González C, et al., 2020) Our comprehensive network of technical, quality and customer engagement teams are ready to support your engineering phage development for biofilm removal. Our experience mentoring new and emerging clients at all stages of formulation development helps save time and costs. Our team also has a proven track record of fast and efficient execution, allowing you to avoid worrying about the progress of your project.
To design phage-based methods for removing biofilms, it is important to consider the specific characteristics of phages that may play a role in their penetration, diffusion and spread through biofilms. For example, biofilm penetration is generally less efficient for larger phages
Some phage-encoded enzymes may help treat bacterial infections and biofilms. These phage-derived enzymes or enzyme biogenesis can be used as an alternative to antibiotics to promote human and animal health. Creative Biolabs offers two main types of phage-degrading enzymes developed for biofilm removal: lysins and depolymerases.
Team at Creative Biolabs facilitates biofilm removal by genetically modifying phages to produce enzymes that degrade EPS substrates
Our team's combination of phage-derived enzymes with antibiotics, such as depolymerases with antibiotics, can increase the antibacterial effect by facilitating the access of antibiotics to bacteria within biofilms.
Creative Biolabs can meet the needs of customers by providing engineering phage development solutions for biofilm removal on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
