Phage Technology in Genetics

Phages have long been studied as vehicles for gene therapy. Similar to other viral vectors, phage coat proteins have evolved over millions of years to protect the viral genome from degradation after injection, protecting valuable therapeutic sequences. What distinguishes phages from other viral gene delivery vectors is their safety for human use and the relative ease with which foreign molecules can be expressed on the outer surface of phages, enabling highly targeted gene delivery. This latter property also makes phages a popular choice for gene therapy target discovery through directed evolution.

Phages provide a rich source of orthogonal elements for synthetic biology, as they have evolved many different gene circuits to control the same gene network to take over the host cell's resources to produce phage progeny. Design and construction of synthetic circuits, a synthetic biology variant of metabolic engineering, has been applied to a wide range of cellular regulatory processes. Creative Biolabs' complete DNA synthesis platform is a one-stop shop for all solutions in the design and synthesis of gene circuits.

Our Solutions

The emergence of a new generation of gene synthesis technologies is represented by our next-generation DNA synthesis platform. This platform provides phage vector development for gene delivery and a one-stop shop for all synthetic circuit design solutions. With advances in sequencing and gene synthesis technologies, our scientists are attempting to reprogram gene circuits and applications. The solutions-based phage we provided are listed below, but are not limited to:

Phages as Gene Delivery Vectors

Filamentous phages allow a variety of proteins, antibodies, and peptides to be displayed on the phage coat, allowing the phage to genetically target cell surface receptors. Creative Biolabs provides the solution that phage vectors can be designed for receptor-mediated gene transfer into mammalian cells.

Design and Synthesis of Gene Circuits

Our designers incorporated phage λ into the design of synthetic circuits. This phage grows lytically, forming stable lysogens, and can transition from this regulated state to lytic growth. Our advanced circuit design concepts pave the way for more complex synthetic cellular regulation.

Our Advantages

Creative Biolabs has proprietary codon optimization software through which customers can optimize their sequences and design synthetic protocols for free.
Our vector allows for the simultaneous production of ssDNA from phage recovered from culture media and the production of dsDNA plasmids from cells.
Creative Biolabs uses next-generation sequencing and proprietary sequencing databases and software to analyze its phages.
Regularly update the process through conference calls or face-to-face meetings.
Best after-sale service with short delivery time, powered by proven best-in-class phage technology.

Creative Biolabs can meet the needs of customers by providing solutions of phage in genetics on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).