The design of tissue engineering materials needs to consider the cellular microenvironment in vivo. In vivo, cells are in close contact with each other and with an extracellular matrix that contains many diffusing factors. Tissue engineering materials provide greater surface area for cell engagement, resulting in improved cell interactions and material integration, as well as cell proliferation and differentiation. Phage engineering offers unprecedented opportunities to create novel tissue engineering materials by integrating principles of biology, chemistry, and materials science. M13 is a bacteriophage (virus) consisting of single-stranded DNA wrapped by various major and minor coat proteins. It has a long rod filamentary shape, approximately 880 nm long and 6.6 nm wide. M13 phage possesses several properties that make it an attractive candidate as a building block for tissue regeneration scaffolds. Through genetic engineering, high-density functional peptides and proteins can be simultaneously displayed on the coat protein of M13 phage. The resulting phages can self-assemble into nanofibrous network structures and can guide tissue morphogenesis through proliferation, differentiation, and apoptosis.
Fig 1. Control of cell growth morphologies using phage tissue engineering materials. (Jin H E, et al., 2018) Creative Biolabs is a global leader in comprehensive phage material solutions for the bioscience industry. We offer a flexible portfolio of comprehensive solutions for phage-related projects including the listed services. We look forward to working side by side with you as a long-term partner you can trust.
Depth and breadth of knowledge: We have many years of depth of knowledge across multiple industries. During this time, we haven't seen much that would allow us to apply this knowledge to improve your business performance.
Expertise: Our focus on improving business performance is our sole focus. We specialize in phage-based materials development, which is why it's important to support yourself in improving any business improvements.
Flexibility: We are never tied to a particular approach, but focus on achieving the results our customers' desire. We meet needs, adapt and provide the most appropriate approach and solution based on business objectives.
Creative Biolabs can meet the needs of customers by providing phage-based tissue engineering materials development solutions on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.
Please kindly note that our services can only be used to support research purposes (Not for clinical use).
Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.
