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Phage-Based Vaccine Development

Phage based Vaccines DevelopmentBacteriophages are specific antagonists of bacterial hosts. These viral entities have attracted increasing interest as the best vaccine delivery vehicles. Due to the high stability, simple and cheap mass production under harsh environmental conditions, and strong adjuvant capabilities, bacteriophages are very suitable for vaccine design. Phage vaccines have an effective immune-stimulating effect and have high safety because these viruses have maintained a continuous relationship with the mammalian body during the long-term evolution process. Phage display vaccines are prepared by expressing multiple copies of antigen on the surface of immunogenic phage particles, thereby triggering a powerful and effective immune response. In addition, the ability to produce combinatorial peptide libraries with highly diverse random ligand libraries has transformed phage display into a direct, versatile, and high-throughput screening method for identifying potential candidates for different diseases, especially microbial infections. vaccine. Phage display provides great hope for finding new strategies for vaccine discovery and production. Current breakthroughs bring a bright future for the development of different phage-based vaccine platforms.

Our Services

At Creative Biolabs, phage-based vaccines development by a platform approach can quickly recover from viruses, thereby providing significant potential. In addition, bacteriophage-based viruses are spontaneous, possibly because they automatically activate an immune response. Phages have a wide range of therapeutic uses in humans and have good safety.There are two main types of phage-based vaccines: phage display vaccines and phage DNA vaccines. The combination of these two strategies led to the development of a third strategy, hybrid phage vaccines.

Phage display vaccines

Phage display vaccines

The types of display systems we used in the vaccine development process are filamentous phage (M13, fd, and f1), lytic phage (T4 and T7), and mild phage lambda (λ).

Phage DNA vaccines

Phage DNA vaccines

DNA vaccination involves the direct administration of foreign DNA encoding an antigen to induce host immunity. At Creative Biolabs, using dendritic cells as a target for transfection has been shown to improve immunity.

Hybrid phage vaccines

Hybrid phage vaccines

At Creative Biolabs, hybrid phage vaccines are produced by a combination of phage display and phage DNA vaccines.

The Advantages of Phage-Based Vaccines

  • Compared with other vaccine technologies, phage-based vaccines have the following potential advantages:
  • Excellent safety of bacteriophages
  • Adapt the new vaccine to the potential mutation of the virus very quickly
  • Compared with alternative vaccine methods, manufacturing costs are lower
  • Self-assisted to enhance immune response

Our Capabilities

  • Vaccine research and development based on advanced technology platform and experienced expert team
  • We are able to provide the best quality service for the development of phage display vaccines
  • High yield, quality and purity of phage-based vaccine delivery

Creative Biolabs can meet the needs of customers by providing vaccine development services on time and on budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.

Reference

  • González-Mora A, Hernández-Pérez J, Iqbal H, et al. Bacteriophage-Based vaccines: A potent approach for antigen delivery[J]. Vaccines, 2020, 8(3): 504.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).

Biophage Technology

Creative Biolabs is a globally recognized phage company. Creative Biolabs is committed to providing researchers with the most reliable service and the most competitive price.

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