Synthetic Biology

Phages are the most diverse and abundant organisms on earth, and they are also important model organisms in synthetic biology research. Phage genomes are relatively small and simple in structure, making them the simplest biological systems to study basic life processes. By editing the phage genome, or even redesigning and synthesizing the phage genome, phages with new functions are obtained. The artificially engineered phages have been successfully used to improve the infection efficiency of phages, regulate the host range of phages, reduce the toxicity and immunogenicity of phages, improve the survival period of phages after administration, and improve the degradation of biofilms by phages. In addition, phage display, phage-assisted continuous evolution, phage-mediated DNA transduction, and the development of phage-mediated biosensors have also become powerful tools in synthetic biology research. In conclusion, the development of synthetic biology will pave the way for the modular design of phages as multifunctional biologics, control of multidrug-resistant bacteria, pathogen detection, drug development, regulation of microbiota, drug delivery, and even phage nanomaterials.

Fig 1. The various components of phages that have contributed to synthetic biology advancements. (Lemire S, et al., 2018)

Our Solutions

Artificially constructed phages are easier to modularize than natural phages. Artificial phages are not only used for the prevention and control of bacterial infections, but also for pathogen detection, food safety, flora regulation, vaccine development, and nanomaterials. The solutions-based phage we provided are listed below, but are not limited to:

Functional Biologics Development

Phages can be engineered to carry reporter genes expressed during infection of the target bacteria and subsequently detected. Creative Biolabs provides solutions for functional biologics development.

Phage for Biofilm Removal

Our team co-designed and developed an engineered phage that expresses a biofilm-degrading enzyme to simultaneously attack bacterial cells in biofilms.

Microbial Community Control

Phages have a highly specific host range and are therefore expected to precisely knock out strains in microbial communities or edit specific genes in microbial communities.

Drug Delivery

The ability of engineered phages to deliver drugs directly to specific cancer cells has the potential to minimize the side effects and off-target toxicity of more traditional cancer therapies.

Biosensor Development

We support biosensors development. Phage-based biosensors have been developed, which have excellent robustness and selectivity, and are easy to integrate into transduction devices.

Nanomaterial Development

Filamentous, MS2, lambda, and T phage particles can be used as designed nanocarriers for targeted delivery of therapeutic agents and diagnostic reporter molecules.

Our Capacities

Creative Biolabs is an R&D and manufacturing entity, and our proprietary formulations and processes optimize the use of phages in commercial applications.
Creative Biolabs develops phage solutions for agriculture, food, water, as well as industrial and pharmaceutical markets.
With years of experience, Creative Biolabs produces and sells tens of thousands of liters of phage products annually.

Creative Biolabs can meet the needs of customers by providing solutions of synthetic biology on time and budget. We have in-depth knowledge and experience of the tools and processes involved in the phage projects. Our skilled and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for your project. If necessary, please feel free to contact us.

Reference

Lemire S, Yehl K M, Lu T K. Phage-based applications in synthetic biology[J]. Annual Review of Virology, 2018, 5(1): 453.

Please kindly note that our services can only be used to support research purposes (Not for clinical use).